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M9490633.TXT
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1994-09-24
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Document 0633
DOCN M9490633
TI Induced mouse spleen B-cell proliferation and secretion of
immunoglobulin by lipid-associated membrane proteins of Mycoplasma
fermentans incognitus and Mycoplasma penetrans.
DT 9411
AU Feng SH; Lo SC; Department of Infectious and Parasitic Disease
Pathology, Armed; Forces Institute of Pathology, Washington, D.C. 20306.
SO Infect Immun. 1994 Sep;62(9):3916-21. Unique Identifier : AIDSLINE
MED/94341899
AB Mycoplasmas have been implicated as a possible cofactor in AIDS
pathogenesis. Mycoplasma fermentans and M. penetrans infect human
immunodeficiency virus-positive patients at a significantly higher
frequency than non-human immunodeficiency virus-infected control
subjects. Various mycoplasmal membrane preparations are known to affect
the functions of immune cells both in vitro and in vivo. A group of
lipid-associated membrane proteins (LAMPs) extracted by Triton X-114
from mycoplasmas are major antigenic targets of human host antibody
responses. In this study, LAMPs prepared from both M. fermentans and M.
penetrans nonspecifically stimulated spleen cells of CBA/CaH mice to
proliferate. LAMPs were also stimulatory to spleen cells from athymic
mice. On the other hand, enriched splenic T cells from CBA/CaH mice with
or without accessory cells responded poorly. Thus, the mitogenic effect
of mycoplasmal LAMPs appeared mainly on B cells. High levels of
immunoglobulin (Ig) M and low but detectable amounts of IgG were found
in the supernatant of LAMP-treated splenic cell culture. M. penetrans
LAMPs had a much more potent effect on murine spleen cells than did M.
fermentans incognitus LAMPs in inducing both B-cell proliferation and Ig
secretion. In conclusion, the mycoplasmal LAMPs contained an active
component(s) with T-independent B-cell mitogenic effect.
DE Animal B-Lymphocytes/*IMMUNOLOGY Bacterial Proteins/*PHARMACOLOGY
Female Immunoblotting Immunoglobulins/*BIOSYNTHESIS Lymphocyte
Transformation/*DRUG EFFECTS Membrane Proteins/*PHARMACOLOGY Mice
Mice, Inbred CBA Mycoplasma/*IMMUNOLOGY Mycoplasma
fermentans/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).